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dendrotoxin k dtx k  (Alomone Labs)


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    Alomone Labs dendrotoxin k dtx k
    Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or <t>quinpirole/DTX‐K.</t> Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
    Dendrotoxin K Dtx K, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 53 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dendrotoxin+k+dtx+k/Dendrotoxin-K/pmc12256973-45-0-7
    Average 94 stars, based on 53 article reviews
    dendrotoxin k dtx k - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus"

    Article Title: Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus

    Journal: The European Journal of Neuroscience

    doi: 10.1111/ejn.70176

    Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or quinpirole/DTX‐K. Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
    Figure Legend Snippet: Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or quinpirole/DTX‐K. Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Techniques Used: Activation Assay, Membrane, Patch Clamp

    Related Articles

    other:

    Article Title: Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice
    Article Snippet: Recordings were performed in the whole-cell configuration using an Axopatch 200B patch-clamp amplifier (Molecular Devices) and a Digidata board (Molecular Devices) under the control of pClamp software (version 8, Molecular Devices).

    Article Title: Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus
    Article Snippet: Dendrotoxin‐K (DTX‐K) and SB‐216763 were purchased from Alomone lab and Hellobio, respectively.

    Article Title: Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice
    Article Snippet: Patch pipettes were pulled from capillary glass (GC120TF; Harvard Apparatus) using a vertical puller (Narishige).

    Patch Clamp:

    Article Title: Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea
    Article Snippet: .. Dendrotoxin-K (DTX-K), TTX, 4,9-anhydro-TTX (4,9-ah-TTX), and sea anemone ( Anemonia sulcata ) toxin ATX-II were all obtained from Alomone Labs. Toxins were prepared as stock solutions in water and stored at −20°C, before dilution in extracellular solution for patch clamp recordings. .. The mouse monoclonal neuronal class III β-tubulin antibody (TUJ1; subtype IgG 2a ; Covance, Princeton) was used as a neuronal marker.

    Article Title: Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea
    Article Snippet: .. Dendrotoxin-K (DTX-K), TTX, 4,9-anhydro-TTX (4,9-ahTTX), and sea anemone (Anemonia sulcata) toxin ATX-II were all obtained from Alomone Labs. Toxins were prepared as stock solutions in water and stored at 20°C, before dilution in extracellular solution for patch clamp recordings. .. The mouse monoclonal neuronal class III -tubulin antibody (TUJ1; subtype IgG2a; Covance, Princeton) was used as a neuronal marker.



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    Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or <t>quinpirole/DTX‐K.</t> Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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    Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or <t>quinpirole/DTX‐K.</t> Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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    Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or <t>quinpirole/DTX‐K.</t> Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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    Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or quinpirole/DTX‐K. Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Journal: The European Journal of Neuroscience

    Article Title: Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus

    doi: 10.1111/ejn.70176

    Figure Lengend Snippet: Implication of Kv1.1 channel in D2R activation‐mediated changes in active membrane properties in SST‐INs and PV‐INs. (A) Left, I–V curve of leak‐subtracted current for tdTomato SST cells from −70 to −30 mV after application of quinpirole or quinpirole/DTX‐K. Mean of leak‐subtracted steady state at −40 mV in SST‐INs after application of quinpirole 10 μM with or without DTX‐ or at −30 mV. Left part: Ratio of decrease for SST‐INs at −30 mV after DTX‐K application. (B as in A) for tdTomato PV neurons after quinpirole 1 μM application with or without DTX‐K at −30 mV. Data are represented as mean ± SEM. Unpaired t ‐test and two‐way repeated measure ANOVA followed by Tukey test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Article Snippet: Dendrotoxin‐K (DTX‐K) and SB‐216763 were purchased from Alomone lab and Hellobio, respectively.

    Techniques: Activation Assay, Membrane, Patch Clamp